ABSTRACT
Suprofen eye drop was instilled into one eye of 10 pigmented rabbits and then anterior uveitis was induced by intraperitoneal injection of endotoxin of Shigella flexneri serotype 1A to evaluate the effects of non-steroidal anti-inflammatory drug on endotoxin induced uveitis. The pupillary diameters were measured, and aqueous cell and flare gradings were recorded in 20 eyes of 10 rabbits for one week at an interval of 12 hours for the first 24 hours and then every 24 hours for a week. A difference between the treated and control groups were investigated. All the above parameters showed greatest changes at 12 or 24 hours after injection and became normal by one week. The two groups demonstrated statistically significant difference at 12 hours, day 1 and day 2 as for pupillary diameter, at day 1 and day 2 as for cell and at 12 hours and day 1 as for flare. Thus, it can be concluded that prostaglandins play a role in miosis, in the appearance of inflammatory cells and flare in endotoxin induced uveitis and the topical administration of non-steroidal anti-inflammatory drug can alleviate signs of anterior uveitis. Specific relationship between leukotriene B4 and aqueous cell was not demonstrated.
Subject(s)
Animals , Rabbits , Administration, Topical , Cell Count , Endotoxins , Shigella flexneri , Suprofen/therapeutic use , Uveitis, Anterior/drug therapyABSTRACT
The results of the present investigation have shown the usefulness of suprofen in the control of pain following surgical removal of impacted wisdom tooth. The regime of 200 mg. q.d.s. orally, was shown to be satisfactory in the control of postoperative pain. Pain was rapidly controlled by the 1st hour after ingestion and subsequently maintained at a low profile until is was completely abolished by the 8th hour of the postoperative period.
Subject(s)
Adolescent , Adult , Drug Tolerance , Female , Humans , Male , Molar, Third/surgery , Pain Measurement , Pain, Postoperative/prevention & control , Suprofen/therapeutic use , Time Factors , Tooth Extraction , Tooth, Impacted/surgeryABSTRACT
Mediante un estudio simple ciego se valoró la potencia analgésica y tolerancia de 400 mg de suprofén y 75 mg de diclofenac sódico, administrado por vía intramuscular a cuarenta pacientes con dolor dental agudo. Suprofén fue estadísticamente superior las primeras cuatro a seis horas observación, en los parámetros de disminución de la intensidad y alivio al dolor, corroborándose esta situación con la valoración global realizada por investigador y paciente, donde se ve un 95% de resultados buenos/excelentes. Se concluyó que suprofén es un medicamento seguro y eficaz en pacientes con dolor dental agudo
Subject(s)
Adult , Humans , Male , Female , Diclofenac/therapeutic use , Suprofen/therapeutic use , Toothache , Clinical Trials as TopicSubject(s)
Adolescent , Adult , Middle Aged , Humans , Male , Female , Pain, Postoperative/drug therapy , Suprofen/therapeutic use , Abdomen/surgery , Analgesics/therapeutic use , Drug Tolerance , MexicoSubject(s)
Child, Preschool , Humans , Male , Female , Fever/drug therapy , Suprofen/therapeutic use , Acetaminophen/therapeutic use , MexicoABSTRACT
La eficacia antipirética de suprofén (jarabe, 5 mg/kg) y dipirona (jarabe, 20 mg/kg) fueron comparadas en niños con padecimientos febriles en un estudio simple ciego, valorando 50 casos. Ambos fármacos redujeron la fiebre desde los 30 minutos de su administración, llevando a normotermia a las tres horas, y manteniendo la temperatura así hasta la sexta hora. Dosis reperidas a las seis, 12 y 18 horas mantuvieron a los pacientes sin fiebre. La forma líquida de suprofén se encontró adecuada debido a la facilidad y exactitud en su dosificación. Los efectos indeseables de ambos fármacos fueron mínimos